Depression and Alcohol Use Disorders are important public health problems worldwide with high prevalence rates, high levels of disability and potentially fatal consequences through suicide, road traffic accidents or health complications such as liver cirrhosis. Psychological treatments such as Cognitive Behaviour Therapy for Depression and Motivational Interviewing for Alcohol Use Disorders have been shown to be effective in western settings. The vast majority of people who live in low and middle-income countries (LMIC) do not have access to these psychological treatments. The main reasons for this are the lack of skilled personnel for delivering treatments and concerns regarding the acceptability of treatments developed in ‘western’ cultural settings. PREMIUM addressed these challenges by developing culturally appropriate psychological treatments for delivery by non-specialist health workers in primary health care settings.